Gonadal hormones .. and the hypothalamus pituitary gonadal axis is reported to have effect on cognition along the lifespan and decline in estradiol and progestin post menopause is associated with more AD risk in females.
Depending the grade of Insulin resistante state in patient (Gut, Adipose, Liver, Muscular) and the optimal function of the Brain-Gut-Axis, the ethinilestradiol, the testosterone, the Dehydrotestosterone and The Progesterone in women, all of this (metilpregnenolone, ever...) hormones dinamic equilibrium, sum the acute cortisol and adrenaline activity, modulates the amygdalar reactivity and the memory process. In acute way, the central brain Insulin determinates the memory consolidation, with the Melatonin control (In acute form, the Insulin Melatonin Axis),