Delta-fos-b, the truncated form of fosB, is accumulated after stimulation with drugs of abuse, among other stimulus. Manipulation of its levels has been made, to my klnowedge, via transgenci mice or viral vectors. I was wondering if there is a way to pharmacologically inhibit its acumulation. Thanks
I don't think you can PHARMACOLOGICALLY inhibit fosB accumulation as the stimulant effects a transcription change that increases fosB. That's why the viral/genetic vectors work - I am not aware of a medication or compound/enzyme (in the pharmacopeia) that would reduce fosB accumulations once the RNA transcription is engendered by the stimulant. You'd have to simply reverse the transcription with a viral vector - which you already know.
Many thanks Colin, I also found that D1 antagonists, such as SCH also have a similar effect, although the literature is very scarce on the subject
BRO RICARDO...
please take alook at this paper...i hope this helps...
Article Small Molecule Screening Identifies Regulators of the Transc...
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