There is some research done on urokinase-type plasminogen activator (uPA) and its role in cancer progression, particularly in cell invasion. Has anyone done some work on detecting the expression levels of uPA and its receptor (uPAR) by glioma cells in vitro (not necessarily C6 cells) and is willing to share some knowledge?
Dear Reaearcher,
can read the following article to see if come with some information.
Int J Oncol. Author manuscript; available in PMC 2007 Dec 1.
Published in final edited form as:
Int J Oncol. 2006 Dec; 29(6): 1349–1357.
PMCID: PMC1661847
NIHMSID: NIHMS12617
SPARC-Induced Migration of Glioblastoma Cell Lines via uPA-uPAR Signaling and Activation of Small GTPase RhoA
2. Suppression of the uPAR–uPA System Retards Angiogenesis, Invasion, and In Vivo Tumor Development in Pancreatic Cancer Cells
Bharathi Gorantla1,
Swapna Asuthkar1,
Jasti S. Rao1,2,
Jitendra Patel3, and
Christopher S. Gondi1
3. Urokinase Plasminogen Activator, uPAR, MMP-2, and MMP-9 in the C6-Glioblastoma Rat Model
PATRICK J. SCHULER1⇓,
MARTIN BENDSZUS2,
SIGLINDE KUEHNEL3,
SVEN WAGNER4,
THOMAS K. HOFFMANN1,
ROLAND GOLDBRUNNER5 and
GILES H. VINCE3
J Cell Mol Med. 2008 Jan-Feb;12(1):174-86. doi: 10.1111/j.1582-4934.2008.00220.x. Epub 2007 Jan 9.
In vivo detection of c-Met expression in a rat C6 glioma model.
Towner RA1, Smith N, Doblas S, Tesiram Y, Garteiser P, Saunders D, Cranford R, Silasi-Mansat R, Herlea O, Ivanciu L, Wu D, Lupu F
J Neurochem. 1998 May; 70(5): 1819–1825.
PMCID: PMC2571951
NIHMSID: NIHMS73238
Evidence for κ- and μ-Opioid Receptor Expression in C6 Glioma Cells
Laura M. Bohn, Mariana M. Belcheva, and Carmine J. Coscia
E. A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, St. Louis, Missouri, U.S.A.
Address correspondence and reprint requests to Dr. C. J. Coscia at Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, 1402 South Grand Blvd., St. Louis, MO 63104, U.S.A.
Author information ► Copyright and License information ►
Thanks,
PR Bollam, MD, MSChe
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