Any good ideas to study and grow the unculturble bacteria?

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Adam B Shapiro

Have you heard of the iCHIP?

http://www.popsci.com/ichip-new-way-find-antibiotics-and-other-key-drugs

Yijie Daniel Deng

Adam, iCHIP is a good technique to isolate bacteria. Many bacteria become culturable once they get isolated. But I am more interested in culturing extremely fastidious bacteria that you already have the isolates, for example, Treponema pallidum.

How about using genomic data and analysis of bacterial metabolism and biosynthetic pathways, so that we know what components are required for their growth.