Resveratrol found in peanut skin inhibits the replication of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in cultured Vero cells. Resveratrol (3,4,5‐trihydroxy‐trans‐stilbene, RES) is a phenolic compound produced by various members of spermatophytes such as grapes, mulberry, and peanuts. It displays potential effects to suppress replication of several viruses including dengue virus (DENV), Zika virus (ZIKV), as well as influenza virus. Resveratrol significantly inhibited the replication of SARS‐CoV‐2 with an EC50 (half‐maximal effective concentration) of 4.48 μM. This suggests that resveratrol has a blocking capacity to the viral entry into cells. These novel data support the potential utility of resveratrol on SARS‐CoV‐2 infection. https://onlinelibrary.wiley.com/doi/10.1002/ptr.6916
Tea Polyphenols epigallocatechin-3-gallate (EGCG) and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro. EGCG and theaflavin, the main active ingredients of green tea and black tea, respectively, are potentially effective to inhibit SARS-CoV-2 activity. Coronaviruses require the 3CL-protease for the cleavage of its polyprotein to make individual proteins functional. EGCG and theaflavin showed inhibitory activity against the SARS-CoV-2 3CL-protease in a dose-dependent manner, and the half inhibitory concentration (IC50) was 7.58 μg/ml for EGCG and 8.44 μg/ml for theaflavin. These results suggest that upon further study, EGCG and theaflavin can be potentially useful to treat COVID-19. https://www.hindawi.com/journals/ecam/2020/5630838/
Quercetin is reported to be effective on treatment and prophylaxis of other SARS like coronavirus infections, as a strong antioxidant and scavenger flavonoid without any adverse events. Upon this data, the investigators hypothesize that quercetin can be effective on both prophylaxis and treatment of COVID-19 cases. https://clinicaltrials.gov/ct2/show/NCT04377789
A combination of blackseed or it's oil, garlic extract, ginger extract, honey, lemon, and Curcuma longa extract has been reported to be effective in helping COVID-19 patients quickly recover at home
Also, A novel antiviral drug called thapsigargin (TG) blocked COVID-19 infection in cells, including all new variants, in a pre-clinical study. See the following useful link: