As research says neuroinflammation is one of the key factor in epilepsy and HMGB1 is one of the important biomarker. Can HMGB1 rapid diagnostic test in blood can be used to differentiate between epilepsy and seizures???
There is a rather quick & yet informative review, downloadable as a lecture in the following link. I hope you find it useful.
http://molmed.org/video/227
Dear Farooq,
HMGB1 can be a biomarker of both: epilepsy (see attached paper 1) and seizures (see the following text: paper's title, abstract and conclusions).
2-Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures
Jieun Choi1*, Hyun Jin Min2 and Jeon-Soo Shin23*
*Corresponding authors: Jieun Choi [email protected] - Jeon-Soo [email protected]
Author Affiliations
1Department of Pediatrics, Seoul National University Boramae Hospital, Seoul National University, College of Medicine, Seoul, Korea
2Department of Microbiology, Yonsei University College of Medicine, Seoul, Korea
3Severance Biomedical Science Institute and Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, Korea
For all author emails, please log on.
Journal of Neuroinflammation 2011, 8:135 doi:10.1186/1742-2094-8-135
The electronic version of this article is the complete one and can be found online at:http://www.jneuroinflammation.com/content/8/1/135
Received:
5 August 2011
Accepted:
11 October 2011
Published:
11 October 2011
© 2011 Choi et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Objective
Febrile seizures are the most common form of childhood seizures. Fever is induced by pro-inflammatory cytokines during infection, and pro-inflammatory cytokines may trigger the development of febrile seizures. In order to determine whether active inflammation, including high mobility group box-1 (HMGB1) and pro-inflammatory cytokines, occurs in children with febrile seizures or epilepsy, we analyzed cytokine profiles of patients with febrile seizures or epilepsy.
Methods
Forty-one febrile seizure patients who visited the emergency department of Seoul National University Boramae Hospital from June 2008 to May 2009 were included in this study. Blood was obtained from the febrile seizure child patients within 30 minutes of the time of the seizure; subsequently, serum cytokine assays were performed. Control samples were collected from children with febrile illness without convulsion (N = 41) and similarly analyzed. Serum samples from afebrile status epilepticus attacks in intractable epilepsy children (N = 12), afebrile seizure attacks in generalized epilepsy with febrile seizure plus (GEFSP) children (N = 6), and afebrile non-epileptic controls (N = 7) were also analyzed.
Results
Serum HMGB1 and IL-1β levels were significantly higher in febrile seizure patients than in fever only controls (p < 0.05). Serum IL-6 levels were significantly higher in typical febrile seizures than in fever only controls (p < 0.05). Serum IL-1β levels were significantly higher in status epilepticus attacks in intractable epilepsy patients than in fever only controls (p < 0.05). Serum levels of IL-1β were significantly correlated with levels of HMGB1, IL-6, and TNF-α (p < 0.05).
Conclusions
HMGB1 and pro-inflammatory cytokines were significantly higher in febrile seizure children. Although it is not possible to infer causality from descriptive human studies, our data suggest that HMGB1 and the cytokine network may contribute to the generation of febrile seizures in children. There may be a potential role for anti-inflammatory therapy targeting cytokines and HMGB1 in preventing or limiting febrile seizures or subsequent epileptogenesis in the vulnerable, developing nervous system of children.
Hoping this will be helpful,
Rafik
Dear AbdulHafeez,
I know Annamaria personally and spent time in her lab when her student Mattio was working on HMGB1
Recent studies reveal that neuroinflammatory changes are common features in epilepsy, and elevated proinflammatory mediators in epileptogenic foci can help characterizing seizures and epilepsy. The HMGB1 is one of the proinflammatory meditors or biomarkers for epilepsy.
- Badges
- Science topic
- Similar topics
- Medicine
- Public Health