Most of the acute rhinitis is due to allergic and non allergic (infective ) causes e.g, influenza virus, rhinovirus etc. What ever the causes of rhinitis, main features are due to the action of chemical mediators released from mast cells or lymphocytes. In this sense histamine has very little role in comparative to other chemical mediators causing rhinitis. So, antihistamine has little role to abate the symptoms. Rather NSAIDs have some role over paracetamol and antihistamines.
But single dose of prednisolone has best action to abate the symptoms promptly with in 10 to 12 hours. We have treated recently 14 cases of acute rhinitis with single dose of 40mg along with famotidine 40mg 12 hourly. About more than 90% symptoms abated with a single dose of prednisolone. Fifty percent of the patients required another dose of prednisolone after 24 hours.
Experiment Findings Single Dose of Prednisolone Can Cure Fever of Dengue in Short Time