A previous study identified 7 main recombination regions (named RC1-7) in the ORF1a, S and ORF8 genes of . The recombination regions RC1-2 and RC3-7 are located in ORF1a and the S1 region of the S gene, respectively.Further analysis showed that two recombination regions (RC6 and RC7) are localized in the receptor binding domain (RBD) of S1, while three other recombination regions (RC3, RC4 and RC5) are localized in the N-terminal domain (NTD) of S1.
RC3 to RC7 correspond to 67-78，137-164，239-262，438-452，468-486 in the S protein.
The indian variant B.1.617 has L452R and E484K in the RC6 and RC7, respectively. Since RBD is very importand for the antibody binding. All vaccine does not work on the indian variant B.1.617.
more detailed infor can be seen
Xin Li, Jia Chang, Shunmei Chen, Liangge Wang, Tung On Yau, Qiang Zhao, Zhangyong Hong, Jishou Ruan, Guangyou Duan, Shan Gao. Genomic feature analysis of betacoronavirus provides insights into SARS and COVID-19 pandemics [J]. Frontiers in Microbiology, 2021, 12(553): 1-20.
Shan Gao
Says who? See this research: "The modest neutralization resistance of the variant spike proteins to vaccine elicited antibody suggests that current vaccines will remain protective vs B.1.617 and B.1.618 variants" [1]. The vaccines used in the study was Pfizer and Moderna mRNA vaccines.
[1] https://www.biorxiv.org/content/10.1101/2021.05.14.444076v1.full.pdf
to Hermann Gruenwald
yes,.
we found all the CoVs has no strong immunogenic abilities, the main reason is that their sequences are from many many times recombinations.
the only way to terminate them is let people stay home for a long time.
vaccine can be used to control, but never termination