ADVIL is anti-prostaglandin. I used it to stop premature labor on 32 year old with 6 children, who delivered her last, a 1400 gm girl, one year ago at 32 weeks. Now at 25 weeks, after overdoing activity for a few days, started with strong contractions every 4 minutes for past 4 hours, with softening of cervix, dilated 2 cm. Treated with 2 Advil and a shot of alcohol, which put her to sleep and stopped painful contractions for 18 hours. Repeated next day in the evening, and again stopped painful contractions. Has anyone else used ADVIL to stop premature labor?
Anti-prostaglandins will cause Patent ductus persistent at birth. Advil= IBUPROFENO
Best: Use Alupent and Cerclaje
Dear Christopher
Is ironic your question (Socratic Method)? Patent ductus persistent at birth for use of Antiprostaglandins. Please Review: Physiology at Birth.
All Have a Happy New Year.
I do not understand your post, Jorge Sarmiento. What are you saying?
I think Dr. Sarmiento means:
Advil is an anti-prostaglandin, which will cause patent ductus arteriosus. So use Alupent and Cerclaje instead.
Advil is an Anti-prostaglandin, which will cause Patent ductus arteriosus or persistent at birth. Advil= IBUPROFENO = Anti-prostaglandin
Best: So use Alupent and Cerclaje instead of Advil. Thanks a lots
Have you tried ADVIL and compared it to ALUPENT? ALUPENT causes much tachycardia and inability to sleep and has not been shown to prevent premature birth: see Cochrane:
no evidence of a reduction in preterm birth (before 37 weeks' gestation) (RR 0.95; 95% CI 0.88 to 1.03, 10 trials, 1212 women). No benefit was demonstrated for betamimetics for perinatal death (RR 0.84; 95% CI 0.46 to 1.55, 11 trials, 1332 infants), or neonatal death (RR 0.90; 95% CI 0.27 to 3.00, six trials, 1174 infants). No significant effect was demonstrated for respiratory distress syndrome (RR 0.87; 95% CI 0.71 to 1.08, eight trials, 1239 infants). A few trials reported on cerebral palsy, infant death and necrotising enterocolitis; no significant differences between groups were identified for any of these outcomes. Betamimetics were significantly associated with the following outcomes: withdrawal from treatment due to adverse effects; maternal chest pain; dyspnoea; palpitation; tremor; headaches; hypokalaemia; hyperglycaemia; nausea or vomiting; nasal stuffiness; and fetal tachycardia.Nine trials compared different types of betamimetics. Other betamimetics were compared with ritodrine in five trials (n = 948). Other comparisons were examined in single trials: hexoprenaline compared with salbutamol (n = 140), slow versus moderate release salbutamol (n = 52) and salbutamol compared with terbutaline (n = 200). Trials were small, varied, and of insufficient quality to delineate any consistent patterns of effect.
AUTHORS' CONCLUSIONS:
Betamimetics help to delay birth, which may give time to allow women to be transferred to tertiary care or to complete a course of antenatal corticosteroids. However, multiple adverse effects must be considered. The data are too few to support the use of any particular betamimetic.
Please make the research tried with 200 patients and compare Advil with Alupent and then publish your conclusions.
Ideally a great idea but I have a small practice without many cases of premature contractions, which is why I asked on this forum!
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