according to my observations and my  experience I think Entamoeba coli is a pathogenic amoeba , because it feeds on bacterial flora in large intestine which play an important role in synthesis of many vital vitamins such as vitamin K , which is an important vitamin for synthesis of vitamin K dependent coagulation factors .

Ent coli also decrease level of potassium and increase level of cholesterol and low density lipoprotein and then it increase risk of heart diseases .

Ent coli also affect the level of vitamin D which is an important vitamins, so it may increase the risk of severe pathological condition and it may lead to cancer in case of chronic Ent coli infection also it may lead to infertility and may affect vital organs such as kidney , because vitamin D deficiency may lead to  many complications such as renal failure directly or by causing diabetes type2 , that may affect kidneys through diabetic nephropathy.

( all the information mention above based on my observation)

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