Presence of ABO group antibodies; Anti A & Anti B in the human sere are due to immunological response of the human body against the carbohydrate antigens present on cell membrane of saprophytic bacteria present in the gut /pollen grains and react strongly with Human RBC antigens A & B in miss match transfusion. Are Anti A & B antibodies a good example of cross reacting antibodies.
Dear Dr. Sharma,
The IgM antibodies are produced against primary infection and the production of other types such as IgG requires reinfection. The IgM antibodies against blood group antigens are produced by allergens, bacteria or other food components during the early life, in which the immune system and innate barriers for infections are at developing stage and it is a short span of time. Once the immune system and the innate barriers are completely developed, the reinfection with a bacteria or exposure to allergens is difficult due to the fully developed innate physical barriers. Since the production of IgG antibodies needs the antigen exposure to the specific B cells, it is impossible for many antigens to cross these barriers. IgG antibodies against blood group antigens are formed only in the case of mismatched blood transfusion or mother-child blood group mismatch during delivery.
I could not find any direct references for this explanation. It is just my understanding after spending some time on this question. I think more experienced immunologists can add more insights on it.
Thanks for the question.
Best regards,
RB
Hi Budida ,
Thanks for supporting my query. hereby I want to focus your attention to my another question that is why A & B antibodies are IgM in humans ? I hop so that you have some justification over the query .
Dear Dr. Sharma,
The IgM antibodies are produced against primary infection and the production of other types such as IgG requires reinfection. The IgM antibodies against blood group antigens are produced by allergens, bacteria or other food components during the early life, in which the immune system and innate barriers for infections are at developing stage and it is a short span of time. Once the immune system and the innate barriers are completely developed, the reinfection with a bacteria or exposure to allergens is difficult due to the fully developed innate physical barriers. Since the production of IgG antibodies needs the antigen exposure to the specific B cells, it is impossible for many antigens to cross these barriers. IgG antibodies against blood group antigens are formed only in the case of mismatched blood transfusion or mother-child blood group mismatch during delivery.
I could not find any direct references for this explanation. It is just my understanding after spending some time on this question. I think more experienced immunologists can add more insights on it.
Thanks for the question.
Best regards,
RB
Hi Budida,
Your justification is appreciable. I also not find the direct answer to the question in literature so what I raised the question among the expertise in the field to get the correct answer or correct myself regarding the subject . Till date what I am thinking or teaching to my students is that there is a subclinical constant immunological stimulus of allergens, bacteria or other food components to the immune system of the body throughout life and there is no primary or secondary stimulus to the immune system so we get the IgM antibodies throughout life till the immune system works actively.
Congratulations for good interaction.
Sir PF_Zabrodskii,
thanks for recommending my question
regards
Initial/naturally produced antibodies are IgM class. After an immunological activation by the present of an antigen or immunogen, the immune system then produces the Immune-response by making and secreting IgG class antibodies. These then will launch an immune reaction against the present antigen/immunogen.
I think this holds water as per the understanding I have.
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