SARS COV2 while still burning through the US, we and other nations have researched practically every topic that this Virus could have. Everything from the Spike Protein on the surface binds to our ACE2-R to the Disseminated Intravascular Coagulation, also known as (DIC). One of the research topics that caught my eyes was the Comorbidities leading to serious outcome cases and unfortunately death.
Mississippi Statistical data shows the number one cause for serious complications and is common comorbidity is Hypertension (HTN) and related cardiovascular disease (CVD), (MSDH, 2021). That said, the problem surrounding HTN and CVD is the increased expression of ACE2-R, thus leaving subjects with increased susceptibility to not only more infection but certainly increased shedding of the virus. This overexpression of ACE2-R is a popular subject in many think tanks and schools of thought.
One would surmise that other comorbidities would have similar if not worse increases in ACE2-R in SARS COV2 infection. Asthma and Chronic Obstructive Pulmonary Disease (COPD), in particular, has a risk in that the pulmonary system is compromised pre-infection which you would think would be a good predictor of severe case outcomes and death. Researchers from the Journal of Immunology and Clinical Immunology found that indeed this was not the case. Interestingly, asthma, COPD, inhaled corticosteroid treatment, and oral corticosteroid treatment were not independent risk factors for ICU admission or death, (Calmes, 2021). Please read the Journal Articles below for your enhanced SARS COV2 knowledge and education.
References:
Calmes, D., Graff, S., Maes, N., Frix, A. N., Thys, M., Bonhomme, O., Berg, J., Debruche, M., Gester, F., Henket, M., Paulus, V., Duysinx, B., Heinen, V., Dang, D. N., Paulus, A., Quaedvlieg, V., Vaillant, F., Van Cauwenberge, H., Malaise, M., Gilbert, A., … Schleich, F. (2021). Asthma and COPD Are Not Risk Factors for ICU Stay and Death in Case of SARS-CoV2 Infection. The journal of allergy and clinical immunology. In practice, 9(1), 160–169. https://doi.org/10.1016/j.jaip.2020.09.04
http://www.msdh.ms.gov/msdhsite/_static/resources/10682.pdf
Nawijn, M. C., & Timens, W. (2020). Can ACE2 expression explain SARS-CoV-2 infection of the respiratory epithelia in COVID-19?. Molecular systems biology, 16(7), e9841. https://doi.org/10.15252/msb.20209841
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