My group is working on the preparation of hydrogel nanoparticles based on chitosan , using the inonotropic gelation method. We are attempting to load different hydrophilic or lipophilic drugs in these nanoparticles. We have faced the problem of drugs escaping from the final nanoparticles. In other words, the drugs exit the nanoparticles and are not able to be entrapped within the carriers. We have tried several methods with no remarkable success. Technical comments from the scientific community in this field would be appreciated.
Actually we are working on a variety of drugs all being hydrophilic, such as lisinopril, gentamicin, etc.
Hydrophilic drugs can release or, deformed or, decreasing activity from hydrogel easily during processing whether the encapsulated hydrophilic drug can retained.
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