We have a stock of pure 99.98% pharmaceutical grade DMSO and we recently ran a UV abs test for 285/275 whch resulted in 0.68 and it is above the 0.65 USP standard.
We are trying to find out the cause of this unplanned degradation, those DMSO are individually aliquoted inside a sterile clear glass bottle in ~50ml and a non-reactive rubber stopper is used together with aluminum cap and stored for about 3 months at room temperature.
Would the UV in office setting light cause a noticeable degradation? or because we did not nitrogen flush the space or maybe some kind of contaminants is introduced?
I am not certain with the introduction of contaminants because the entire batch was affected, unless the tech introduced large amount of weird stuffs by accident such as forgot to rinse the sterile filling nozzle after detergent/chemical treatment. Just by introduce a few droplet of water should not have such strong effect.
Can anyone work closely with pure DMSO shed some light?
Thank you
First of all, I would check whether the UV-spectrum was correctly recorded. Replace DMSO with water and see what happens
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