Hi, In the simple reaction of the synthesis of 4-Amino-5-(4-hydroxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione, are there any expected side products?
Hello:I would say your by product would be 1, 3, 4- Oxadiazole- 2(3H) - thione, 5- (4- hydroxyphenyl) -
Molecular Weight: 194.21. You can also try to make this compound from. 4-hydroxy-benzoic acid with hydrazinecarbothiohydrazide. ( A method for preparing 4-amino-5-aryl-1,2,4-triazole-3-thione.
By Liu, Yuting et al
From Faming Zhuanli Shenqing, 103130731, 05 Jun 2013). Or perhaps make the thiohydrazone then treat it with hydrazine again to get the ring. ( Synthesis and antibacterial activities of novel S-β-D-glucosides of 1,2,4-triazole.
By Zhang, Ruibo et alFrom Youji Huaxue, 35(4), 858-864; 2015.)
Asim
This reaction has been reported to furnish your target molecule in 80% yield, see
---Chande, Madhukar S. et al Canadian Journal of Chemistry, 85(1), 21-28; 2007 (enclosed)
As for a byproduct out of your reaction please note that you have to isolate, purify and get spectral data to assign structure. If you need help then just ask.
Good luck
Dear All
Thanks a lot for your response
I am synthesizing compounds (their general structure shown in the attached file), I am getting pure product with unexpected H NMR signal at 5.7 ppm (2H), which makes me confused and thinking about other products may be formed in the step of the synthesis of the starting material!
Hi Asim,
Hope everything is going well with your work. If you send me a MestreNova file for the NMR spectrum of the impurity plus a reaction scheme then perhaps I could help.
Hi Heulyn,,,
Thanks for your response, I think there is a problem with the purity of one of the starting materials, we are working on it, I will check and update you.
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