Central Nervous System

How to rank new chemical entities based on their chemical properties and PK properties?

For example, during the process of CNS lead optimization, compounds will be measured for potency, selectivity, CYP inhibition profile, solubility, BBB permeability, toxicity, etc. How are the...

01 January 1970 1,921 2 View

Why lead is most dangerous to children?

Lead is most dangerous to children, especially those under six. According to CDC nearly one half of a million children living in the United States have levels of lead in their blood that exceed...

01 January 1970 4,722 9 View

Looking for an article

Lymphatics of the Central Nervous System: Forgotten first descriptions. (S39.003) Daniel Moreno-Zambrano, David Santana, David Avila, Rocío Santibáñez Need this article as soon as possible. Thanks

01 January 1970 7,223 3 View

Need any live research subjects? Those of us with APS that manifests via CNS would love some scientific confirmation?

Are you looking at whether it is micro-clotting (as some surmise) or some other mechanism that affects the nerve endings?

01 January 1970 6,261 2 View

Nerve fiber crossing

why do nerve fibers in the central nervous system cross the midline? what is the biological meaning, if any, of this anatomical zigzag?

01 January 1970 5,882 4 View

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01 January 1970 9,000 0 View

Why lead is most dangerous to children?

Lead is most dangerous to children, especially those under six. According to CDC nearly one half of a million children living in the United States have levels of lead in their blood that exceed...

01 January 1970 1,360 16 View

Significance of Insulin being sytesized and secreated in the brain

I recently found out that Mazucanti CH et al had discovered that insulin was synthesized in the choroid plexus within ependymal cells of the brain. I was very excited to learn this as a source...

01 January 1970 9,757 6 View

How to rank new chemical entities based on their chemical properties and PK properties?

For example, during the process of CNS lead optimization, compounds will be measured for potency, selectivity, CYP inhibition profile, solubility, BBB permeability, toxicity, etc. How are the...

01 January 1970 5,334 2 View

How do viruses affect MS?

Viruses such as Epstein Barr, cause stress to the CNS, which then activates mMC that begin an unending inflammatory cascade resulting in activation of Th-17 pathogenic lymphocytes, oxidative...

01 January 1970 7,293 3 View

Nerve fiber crossing

why do nerve fibers in the central nervous system cross the midline? what is the biological meaning, if any, of this anatomical zigzag?

01 January 1970 5,373 3 View

Need any live research subjects? Those of us with APS that manifests via CNS would love some scientific confirmation?

Are you looking at whether it is micro-clotting (as some surmise) or some other mechanism that affects the nerve endings?

01 January 1970 716 2 View

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01 January 1970 5,441 0 View

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01 January 1970 6,910 0 View

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01 January 1970 9,664 0 View

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01 January 1970 1,895 0 View

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01 January 1970 6,900 0 View

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01 January 1970 8,880 0 View

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01 January 1970 9,098 0 View

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01 January 1970 8,605 0 View