Rene Mulder

10 Questions 38 Answers 0 Followers

Questions related from Rene Mulder

Hi, is there anyone who wants assistance with interpretation and/or classification of mutations to determine possible causality?

While doing research on genes possibly involved in a specific phenotype, you can run in to several difficulties for the interpretation and classification of mutations found, consequently making...

13 October 2017 8,691 2 View

What is the optimal way to search if a SNP is known?

When you sequenced a gene and you found a variant what should you do to know if this variant is known? In this I would first only like to focus on search through SNP databases. In this regard...

22 October 2015 4,241 2 View

Is there a simple way to determine if a mutation introducing a premature stopcodon signals nRNA degragdation?

I have recently found a mutation that leads to a premature stopcodon. I now want to know if this mutation could result in nonsense-mediated mRNA decay. Are there ways to do this?

17 December 2014 7,587 5 View

Is there a database/source for dinosaur DNA and/or protein sequences?

I want to study specific protein sequences to better understand their functional properties. I think that such information from this group of animals may help in this understanding.

16 July 2014 8,887 2 View

Is there a way to determine the age of a novel mutation in humans that is associated with a clinical phenotype?

I have recently identified a novel mutation, but want to know the age of it. Are there any good methods/servers to do this?

17 June 2014 1,044 6 View

Protein-protein interactions: are there any reliable programs to predict interaction between proteins using homology-based molecular structures?

I want to know how two proteins of interst interact with each other by using their homology-based molecular structure. I know from experimental data which part of each protein is required for...

09 April 2014 4,112 10 View

Looking for protein-protein docking software. Any suggestions and experiences?

Would like to get some assistance with simulating/estimating the interactions between two proteins to beteer understand structure-function properties.

24 October 2013 5,447 8 View

How to write a good grants proposal?

I want to continue my career in Academia in the field of bioinformatics.

15 October 2013 4,398 3 View

Where to publish your data?

If you have data on phylogenetics, functional divergence and 3d structures, where should you publish it?

11 October 2013 2,436 6 View

I want to identify amino acid residues that are responsible for functional differences between paralogs. Any help?

There are several servers and software packages that address this question. However, DIVERGE (http://xungulab.com/pub.html) has been most succesful in determining such regions. Unfortunately, I...

13 September 2013 758 17 View