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Questions related from Rene Mulder
While doing research on genes possibly involved in a specific phenotype, you can run in to several difficulties for the interpretation and classification of mutations found, consequently making...
13 October 2017 8,750 2 View
When you sequenced a gene and you found a variant what should you do to know if this variant is known? In this I would first only like to focus on search through SNP databases. In this regard...
22 October 2015 4,280 2 View
I have recently found a mutation that leads to a premature stopcodon. I now want to know if this mutation could result in nonsense-mediated mRNA decay. Are there ways to do this?
17 December 2014 7,664 5 View
Control groups like the HapMap use chrom. sample count by which the frequency per genotype is given. Does this imply that you should also use the chrom. sample count of the cases, e.g. 100...
26 July 2014 2,295 2 View
I have recently identified several snp's from one gene in one population. I want to correlate the genotype with a reference like HapMap. However, the distribution of all snps is heterogenous....
18 July 2014 1,483 23 View
I want to study specific protein sequences to better understand their functional properties. I think that such information from this group of animals may help in this understanding.
16 July 2014 8,950 2 View
I have recently identified a novel mutation, but want to know the age of it. Are there any good methods/servers to do this?
17 June 2014 1,092 6 View
I want to know how two proteins of interst interact with each other by using their homology-based molecular structure. I know from experimental data which part of each protein is required for...
09 April 2014 4,162 10 View
Some proteins are present in human plasma in both free and bound form. In most cases the free fraction exhibits (co)factor activity. However, the underlying mechanism responsible for binding, and...
12 February 2014 3,735 1 View
Would like to get some assistance with simulating/estimating the interactions between two proteins to beteer understand structure-function properties.
24 October 2013 5,509 8 View
I want to continue my career in Academia in the field of bioinformatics.
15 October 2013 4,461 3 View
If you have data on phylogenetics, functional divergence and 3d structures, where should you publish it?
11 October 2013 2,499 6 View
There are several servers and software packages that address this question. However, DIVERGE (http://xungulab.com/pub.html) has been most succesful in determining such regions. Unfortunately, I...
13 September 2013 803 17 View
