Kulvinder Singh Saini

7 Questions 17 Answers 0 Followers

Questions related from Kulvinder Singh Saini

Apart from vaccination, what are the best routes for new drug discovery research against "drugable" targets of Dengue virus?

Since vaccination against Dengue has become crowded field (please see attachment), what are other therapeutic modalities in various stages of discovery and development by biotech/pharma companies?...

17 October 2016 1,202 7 View

What are pros and cons of isolating cancer stem cells (CSCs) from established cell lines vs. primary tumors, for targeting CSCs with new drugs?

There are a number of reports for and against isolating CSCs from established cancer cell lines. One of the best work from Prof. Max Wicha lab, where they isolated CSCs from 33 breast cancer cell...

20 April 2016 9,951 4 View

Do you know any Biotech/Pharma company working on NFkB pathways for developing drugs against inflammatory diseases having molecules in phase-2 or 3?

Like P53, NFkB has been a difficult gene target to discover and develop new drugs? Any thought of targeting NFkB pathway for new drug discovery against inflammatory diseases? Strengths,...

22 September 2015 9,990 4 View

Do you foresee that human-induced-pluripotent-stem-cells generated human tissue will be able to replace animal models in new drug discovery R&D?

Number of reports recently, where hiPSCs were used for generating various human tissues, have received a lot of media publicity. Of course, the scientific merit and the potential implications are...

30 March 2015 5,837 4 View

Does anyone know a potential new biological entity/molecule(s) with miRNAs/RNAi backbone in late-stage clinical development against cancer/ obesity?

Latest data from net I was able to see is from June 2014, and was wondering, if any promising phase-3 clinical development has taken place in the last 9 months? Any of these potential...

23 March 2015 5,137 1 View

Apart from ob/ob and Leptin mice, which other rodent models of obesity are employed for proof-of-concept studies of small molecule compound(s)?

We would like to evaluate small molecule compound(s), where exact mechanism-of-action is not clear at the moment. We are conducting in vitro studies right now and would like to extend these...

15 March 2015 4,762 3 View

Where can we source New Chemical Entities (NCEs) against breast cancer, which failed in phase-1 or 2 clinical trials?

Does anyone know, if global pharmaceutical/biotech companies/NIH, USA/USFDA, NGOs, etc. will be willing to give/sell us small amounts (mg quantity) of their small molecule compounds (NCEs), where...

09 December 2014 5,017 5 View