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Questions related from Kelly Bugatti
I performed an Ulmann type reaction bewteen 2-pyridone and bromobenzene, with these reaction conditions in a schlenk tube: - 0.3 eq CuI - 2 eq of K2CO3 - 1 eq of pyridone - 1.1 eq of...
11 March 2024 3,951 2 View
I need to click a peptide (8 aminoacids) to a probe functionalized with maleimide moiety. The peptide contains a Lys, a terminal NH2 Leu and a Cys. What are the condition to make the reaction...
13 January 2023 8,691 2 View
I have to cleave Trt group from the thiol of the cysteine: I kept the reaction to stir in TFA:TIS:H2O 95:2.5:2.5 (5 mL for 0.7 mmol) for 2 hours, but the reaction didn't go to completion (around...
17 November 2022 1,137 0 View
I work with peptide/peptidomimetics (1600-1800 Da) and when I perform Mass Analysis (flow injection, ACQUITY Ultra Performance LC; ESI, positive ions, Single Quadrupole analyzer) I often find...
16 July 2021 5,179 4 View
I'm used to synthesize peptide using the Fmoc-based Solid Phase Peptide Synthesis, with HATU/HOAt as coupling reagents. This time, after the cleavage from the 2Cl-Trt resin, I see the peaks of...
27 May 2021 7,602 1 View
I have to cleave a terminal primary amine from the 2-Chlorotrityl Resin and I have to mantain the rest of the protected peptide (Boc/tBu protecting groups). I usually use a solution of 3/1/1...
05 May 2021 9,272 4 View
I am working with N-Benzyl substituted indazole-nucleus but I'm having many problem with the stability of the molecules. Does anyone know if the benzyl position is sensitive to something, such as...
30 June 2020 7,702 3 View
I did the reaction shown in the image attached to this question, reported in the article with DOI: 10.1021/jm900431g I need the first product (the ortho-nitro substituted one), but I have always...
19 January 2019 7,324 5 View