I have to cleave a terminal primary amine from the 2-Chlorotrityl Resin and I have to mantain the rest of the protected peptide (Boc/tBu protecting groups).
I usually use a solution of 3/1/1 acetic acid/trifluoroethanol/dichloromethane for the cleavage of the terminal carboxylic acid (without removing the Boc/tBu protecting group): does it work for having terminal amines too? Do you have other acid solution to suggest me?
Thank you in advance.
Dear Kelly Bugatti many thanks for your interesting technical question. Please have a look at the following relevant article which might help you in your analysis:
2-Chlorotrityl Chloride Resin—Studies on Anchoring of Fmoc-Amino Acids and Peptide Cleavage
Article 2-Chlorotrityl Chloride Resin—Studies on Anchoring of Fmoc-A...
This article has been posted as public full text on RG and can bee freely downloaded as pdf file.
Good luck with your research! 👍
Thank you Frank T. Edelmann for showing me this article!
Good luck to you too :)
Check https://www.researchgate.net/publication/21239299_2-Chlorotrityl_Chloride_Resin-Studies_on_Anchoring_of_Fmoc-Amino_Acids_and_Peptide_Cleavage
Also check https://www.longdom.org/open-access/basic-concepts-of-using-solid-phase-synthesis-to-build-small-organic-molecules-using-chlorotrityl-chloride-resin-2329-6798.1000113.pdf
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