Dear Jenny Ure, the variety of neurodegenerative disease is rather great. It would be a surprise if all degenerative diseases could be detected by scanning the retina.

yes, it would. and a recent paper showed that amyloid plaques can be detected in the retina using fluorescent imaging much earlier than expected...

Dear Jenny Ure, the variety of neurodegenerative disease is rather great. It would be a surprise if all degenerative diseases could be detected by scanning the retina.

I believe that the laser procedure laid down in Article, may be used to monitor the status of the retina at different periods of the disease. I agree with Enrico Marani. Dear Jenny.  In order to confirm your interesting suggestion about the diagnosis of neurodegenerative diseases (that is, outside of the retina), more research is needed.

Dear Jenny, The retina shows us more and more on degenerative disesases. But so-called "dégenerative diseases" now reveal to be a mixture of disorders -in which are involved a large number of mechanisms (proteins misfolding, dydphosphorylation... and also association of various diseases, including the "mixed vascular and degenerative disorders). Laser examination will likely be another useful tool!

Dear Jenny. I don´t think the focal changes (very vaguely discribed) will be enohg for setting a diagnosis of degenerative disease.  I am sure, at first You should have Your clinical diagnosis and then You can add further auxilliary investigation. There are many neurological diseases (also degenerative) with no changes of retina.

Sincerely, Edvard Ehler

I don't quite agree with the position of the authors. I have been working for many years with different profiles of neuropsychiatric patients. At the same time, I explore cerebral hemodynamics and area of the eye and optic nerve in all these patients. Age-related degenerative changes in the structure of the eyeball and optic nerve are visualized very often during ultrasound observating in patients with neuropsychiatric profile. On the other hand, disorders of ocular blood flow in arteries often cause local degenerative changes in the eye and the absence of such changes in the eyeball. On the third hand, it is now proved the possibility of developing degenerative diseases of the brain against the backdrop Flammer syndrome as a manifestation of decompensated depletion CNS.

Dear all. We all understand the correctness of each procedure on a patient. If there are degenerative changes in the retina of the eye (there is a saying that "the retina is the brain which is submitted to the periphery"), then we have to check the probability of the existence of neurodegenerative changes in the brain. So, we can assume the existence of such changes, but do not argue. Until then doubt until you are sure of the facts with the help of reliable methods.

Dear Jenny. I have to say - degenerative changes of optic nerve neurons could be detected in the retina (by Scanning laser ohpthalmoscopy). But, brain diseases are different, they can be divided into various groups. It is not possible to speak of neurodegenerative diseases - but about ALS, Parkinson´s disease, Alzheimer, etc. It would be more rational to concentrate on one group of such disease or only on 1 disease.

Sincerely, Edvard

Dear All....

I believe that this is a multifactorial problem and that's just one of the procedures which can be useful. I agree with some reviews that mention that in some degenerative diseases do not find that finding.....

Approaches must be diverse: Biochemical markers, Genetic, Molecular, Neuropsychological instruments etc ... Remember that in most neurodegenerative diseases are due to meet the approved societies and international organizations and the particular criteria so established by the Hospital to that belongs

Sincerely,  Genaro G Ortiz.

Dear all. We are all aware that many of the processes in the living body are interrelated. We understand that the processes occurring in the retina may reflect processes occurring in the brain tissue. If this were always the case, there would be a fairly simple method to evaluate the pathological processes in the brain as the retina. But unfortunately, there is no strict correlation between the processes in the retina and the brain. Therefore, analysis of the retina may be help for more in-depth analysis of the processes in the brain.