I have a case group and a control group, which is age-sex-matched with ratio 1 case: 2 control. I'm wondering what test is suitable to test their mean difference. To test matched groups, some suggest paired t test, some use independent t test. But I find difficult to use paired t test because they are not 1:1 but 1:2.

I found it is difficult to treat it as matched sense if it is not 1:1 ratio. Any idea? Thanks

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