Would you please kindly tell me is it necessary for the research vector to be match with clinical vector?
I’m a beginner of CARs filed and need to know how can I choose my research vector?
I’m on in vitro stage of project development and still need to do additional testing before moving into GMP lentivirus production and I want to choose a 3th generation lentiviral vector to express my sequence in CAR-T cells. I would like to know which vector is suitable for research phase. Would you please kindly suggest me suitable 3th generation lentiviral vector for research, animal studies and then GMP stages. I want to design a construct that is capable to be used in all vectors in different stages of my study, research, animal phase and GMP stages.
Short answer: the research vector does not need need to match the clinical vector initially, but the longer you proceed with a vector the more difficult it will be to change before going into trials.
However, if you want to use a vector to make a product you can't just buy one off the shelf and use it commercially - you will need to have a licensing agreement with the company that makes the vector and they can cost millions. So that's a question for your legal department.
Thanks for your kind answer
now would you please tell me some companies that make such clunical vectors?
I would simply buy several and test using your transgene and promoter etc to see which one performs the best. Then approach the company re a licensing agreement
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