Subroto Chakrabartty All most every country restrained themselves from using it in either treatment or in prevention SIR !

In Italy hydroxychoroquine is not recommend both for the treatment and the prophylaxis of SARS CoV2 infection.

The drug can only relieve inflammation and has no thing to do with prevention of the disease. it also should be considered that the drug has a wide range of side effects. Therefore it is not recommended.

If you are speaking of the commercial medication Hydroxychloroquine used for malaria and various autoimmune diseases, that is synthesized in the lab and contains less than 10% of the desired enantiomer, then no. On the other hand, if you are speaking of a similar chemical, l-quinine, that is 100% natural enantiomer, that has been shown to be anticoronaviral in vitro, and is being considered for prophylaxis in SARS-CoV exposure, then maybe after testing completed. More research needed before it is written off. Thank you.

Subroto Chakrabartty All most every country restrained themselves from using it in either treatment or in prevention SIR !

there is a significant difference in the number of COVID-19 cases as well as deaths in the malaria endemic zones in comparison to the zones which have eliminated malaria. Whether it is due to the immunological effects of frequent malaria infections or due to frequent exposure to chloroquine (including seasonal chloroquine prophylaxis in some areas) is a matter of conjecture. Malaria induces the human adherent peripheral blood mononuclear cells (PBMC) to hyperrespond to subsequent ligation of Toll-like receptor 2 along with with increase of H3K4me3 at important immunometabolic promoters through an epigenetic modification. In fact a heterologous protection may be provided by malaria through promotion of trained immunity. Chloroquine has specific interactions with sugar-modifying enzymes or glycosyltransferases within human cells and may exert antiviral actions through the Inhibition of glycosylation. Chloroquine inhibits quinone reductase, a structural neighbour of UDP-N acetylglucosamine-2-epimerases which are enzymes involved in sialic acid biosynthesis. It may be remembered that sialic acid moieties are present in HIV -- 1 glycoproteins and SARS

coronavirus as well as COVID 19 coronavirus receptor ACE2. Hence the inhibitory effects of chloroquine on vir uses like HIV, orthomyxoviruses and coronaviruses may be also exerted through the inhibition of sialic acid biosynthesis . Chloroquine leads to the alkalinisation of acid vesicles that inhibit the growth of several intracellular bacteria and fungi. However in case of viruses,it leads to the inhibition of uncoating and/or alteration of post translational modifications of newly synthesised proteins, especially inhibition of glycosylation

..from an unpublished paper by Dr Soumya Roy