Paclitaxel IV solution is commercially available which contains Cremophor EL and ethanol at 50:50 ratio.
As Cremophor EL has several drawbacks and side effects.
So, Why Tween 80 and Ethanol combination was not selected for the formulation?
What was the drawbacks of tween 80 over Cremophor EL?
See reference:
Coors, E. A., Seybold, H., Merk, H. F., & Mahler, V. (2005). Polysorbate 80 in medical products and nonimmunologic anaphylactoid reactions. Ann Allergy Asthma Immunol, 95(6), 593–599. http://doi.org/10.1016/s1081-1206(10)61024-1
Thanks a lot for the reference.
However, cremophor EL is also immunogenic and show hypersensitivity reaction as tween, till then they are used for pharmaceutical formulations.
Is there any issue related to solubility of paclitaxel in tween: ethanol solvent system?
I guess different surfactants have similar adverse effects - the preference of cremophor instead of tween might be due to other reasons like solubilily or surface activity aspects like micelle size. The solubility of paclitaxel in Tween 80 was investigated in this paper: https://www.researchgate.net/publication/6438426_Enhanced_solubility_and_stability_of_PEGylated_liposomal_paclitaxel_In_vitro_and_in_vivo_evaluation
Article Enhanced solubility and stability of PEGylated liposomal pac...
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