How does the injection volume impact LLOQ and ULOQ in regression analysis (LC-MSMS)?

Hello, I have run into an issue that has sparkled a debate at work: is the LLOQ/ULOQ impacted by injection volume under the following circumstances: 1) Same dilution factor of all samples 2)...

23 February 2021 9,159 3 View

Has any research on translation investigated the phenomenon of bilingual authors who produce versions of their books in both their languages?

Can the second-language version, strictly speaking, be considered a translation of the first-language version or is it merely a somewhat looser interpretation? How do such authors approach the...

10 December 2020 5,092 25 View

How to distinguish CA1 pyramidal cell vs. interneuron using voltage-clamp?

I am doing voltage-clamp experiments in CA1 pyramidal cells (mEPSCs; AMPA-NMDA ratio; LTP; etc) from acute hippocampal slices in mice. I want to make sure I am only recording from excitatory...

29 October 2020 1,098 2 View

Increase Oleophilicity while decreasing hydrophilicity on silicon surfaces?

Hello RG community, currently I am trying to reach these goals on silicon surfaces for a microfludic project. I have used silanes like APTES in the past in order to get my si-surface hydrophobic...

22 March 2020 2,925 3 View

How could one improve the magnitude of t-statistics of a construct?

Hello All, I am not even sure if this is possible, but I have used this dataset for several publication -albeit with different constructs-and have not seen such low t-values. For example, I have a...

10 March 2020 1,164 3 View

How do I calculate the Mean and Standard Deviation for a set of items (i.e., that form a construct) in SPSS?

Hello All, I have been asked to supply the Mean and Standard Deviation for my latent constructs. Is there a straightforward way of doing it in SPSS? I am actually modeling in SmartPLS, but not...

04 March 2020 1,597 4 View

Any strategies for quantification and purification of a red pigment with no peaks in the visible region which is only soluble in water?

We have isolated a red pigment producing bacteria. We harvested the crude pigment by removing the cells by centrifugation. We tried to find the absorption maxima (lambda max) of the pigment using...

19 January 2020 1,331 2 View

How to Create Small Graphs for Interaction Effects?

Hello All, I have been able to calculate all the interaction effects for a study involving the Big Five. One of the interaction effects I would like to graph (among others) is the relationship...

30 December 2019 6,640 3 View

Can you have stop codon right before a RBS (Shine-Dalgaro) site?

I am designing a primer for a gBlock and I don't want to the poly-histag. So naturally I am adding a stop codon in my primer, but then I need a new RBS site. So my question is can I have a stop...

28 July 2019 1,675 2 View

XML haar cascade for red blood cells and/or echinocytes ?

Hello community, we currently working on an automatic algorithm for erytrocyte detection in stereo-microscopy images for cell counting. Additionally we want to determine the percentile amount of...

23 October 2018 3,262 2 View

Shall I skip the measurement model in SmartPLS?

Hello everyone, I had run a mediation model in SmartPLS using questionnaires that were already validated among my statistical population. A professor who edited my paper -though she is not...

01 March 2021 3,052 3 View

What should I do if the reviewer couldn't finalize the review in the journal's given time?

I have Submitted 2,3 Papers in Science Direct associated Journals but the time of the first decision has been ended so What should I do? Could I email them to remind them about the first decision?

01 February 2021 5,788 7 View

How do you annotate figures to show significance?

30 January 2021 1,008 3 View

How can I generate a population with a fixed correlation coefficient in R?

I want to generate an artificial population using two variables (say x & y) with a fixed correlation between x & y. Which package/command in R software can help in this?

18 January 2021 2,545 9 View

Compare to prevalence before and after covid in population studies?

Dear researchers, I have a prevalence of some diet habit in relatively large narrow population of children 13 years old in 2019 and 2020. Logically they are different population. However, since...

10 January 2021 3,170 9 View

What is the optimum Wolbachia population that can significantly affect dengue cases in densely populated provinces in the country?

I am working on a paper that looks into the dynamics of the spread of Wolbachia and its potential impact on dengue transmission, particularly in the Philippines.

29 October 2020 6,723 3 View

What is the meaning of an adjustment for confounding factors in the context of multiple regression analysis and epidemiology?

I have reformulated the question I mean a statistical approach for adjusting values using multiple linear regression which is often used in ecological studies (e.g. Urashima et al., 2020 Int J...

13 October 2020 3,142 5 View

How write a concept note on Evaluation of community-based primary prevention models for NCDs?

1. What type of literature should I read for writing a successful concept note? 2. Is there any literature which will help me decide a research question/objective for designing a study will be...

12 October 2020 3,363 5 View

What statistical analysis can I use to select individuals from a population of a dioecious species?

I have a population of a dioecious species with significant phenotypic variation and want to select individuals from this population. What statistical methods can I use to perform multi-trait...

11 October 2020 598 12 View

What is expected from a PhD ?

PhD is considered as the highest degree one can get from the university and also is recognized worldwide. What is expected out of a PhD degree, the holder and the providing institutes ? What are...

11 October 2020 9,412 13 View