Cocrystal engineering has become of such great importance in the field of pharmaceuticals.
Cocrystals are very relevant for pharmaceutical industry. By cocrystallization , you can attempt directly to tailormake properties of APIs at the crystal level. This aids in easy formulation approaches without the addition of surfactants and other chemical excipients to enhance the pharmaceutical properties of APIs like stability, solubility etc. A direct impact on bioavailability of API can be made by cocrystallization
In fact, crystal forms are gaining increased importance in the pharmaceutical and chemical industries as an good way to modify the physicochemical properties of organic molecules.
Co-crystallization is supposed t indicate that 2 different materials are precipitated together in the same crystal lattice. It can be used for drug and additives (excipients), and here we aim to improve stability and solubility of the drug by precipitating it in amorphous form inside the crystal lattice, or protecting some functional groups such as the case of cycodextrins complexation. And this what usually pharmaceutical industry refer to.
On the other hand, another more interesting application is co-crystals of pharmaceutical additives (excipients) together, at which we improve the characteristics of these additives by combination of 2 different types. We can improve compressibility of the excipient, or disintigration ability, porosity, ....etc.
- Badges
- Science method
- Similar topics
- Methodology
- Crystallography