I'm currenty working on the antifungal activity of iron nanoparticles incorporated in a polymeric matrix. I've conducted the test against C.albicans and F.oxysporum but there is no antifungal activity. Is it due to the wall structure in fungi species?
Iron oxide nanoparticles have been shown to have antifungal activity against various fungal pathogens. However, it is important to note that not all iron nanoparticles have antifungal activity. The reason for this is not entirely clear, but it may be due to differences in the size, shape, and surface properties of the nanoparticles. Additionally, the type of fungus being targeted may also play a role in the effectiveness of the nanoparticles.
Iron nanoparticles typically do not exhibit inherent antifungal activity due to several reasons. Firstly, the primary mode of action for many antifungal agents involves targeting specific cellular processes or structures that are unique to fungi. Iron nanoparticles, on the other hand, do not possess specific mechanisms to target fungal cells or disrupt their growth.
Secondly, the cell wall structure of fungi plays a crucial role in their resistance to various antifungal agents, including nanoparticles. Fungal cell walls consist of complex layers of polysaccharides, proteins, and other components that provide structural integrity and protection against external threats. This barrier can prevent the direct interaction of iron nanoparticles with fungal cells, limiting their antifungal activity.
Moreover, iron nanoparticles may undergo oxidation or aggregation in the presence of environmental factors, such as moisture or oxygen, which can further diminish their potential antifungal effects.
It's important to note that the efficacy of nanoparticles as antifungal agents can vary depending on their size, surface properties, and coating materials. While iron nanoparticles may not exhibit significant antifungal activity, other types of nanoparticles (e.g., silver, zinc oxide) have been extensively studied for their antifungal properties.
Raza MA, et al. (2016). Green Synthesis of Iron Nanoparticles and Their Environmental Applications and Implications. Nanomaterials, 6(11), 209.
Article Green Synthesis of Iron Nanoparticles and Their Environmenta...
good luck