Asthma is a chronic, obstructive disease;
In asthma we have hypersecretion of mucos ;the main component of mucos is mucin ; the main airway mucins are muc 5ac and muc 5b that are released from goblet cell and submucosal glands ,respectively.
Asthma characterized by some changes, like: thickening of the lamina reticularis, epithelial shedding, subepithelial fibrosis, inflammatory cell infiltration, goblet cell hyperplasia, myofibroblast proliferation, smooth muscle hyperplasia and hypertrophy, and neovascularization of the airway wall
According to the findings ; increased amount of the muc5ac and decreased amount of muc5b is observed.
Goblet cell hyperplasia can cause more expression of muc5 ac but there is no evidence for the reason of decreased amounts of muc5b .I'm looking toward this decreasing reasons.
I will be thankful if you share your ideas with me .
"The changes in mucin gene and protein expression in asthma most likely reflect the activity of IL-13 because IL-13 is well known to cause increases in MUC5AC and decreases in MUC5B in airway epithelial cells in vitro and in murine models." Article Abnormalities in MUC5AC and MUC5B protein in airway mucus in asthma
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