Why do I need to stain for MHCII DR (instead of say MHCII DQ) when looking at porcine intestine with immunohistochemistry?

02 February 2017 1 8K Report

All I can seem to find is that DQ, DP and DR are involved in antigen presentation, whilst DM and DO are involved in peptide loading. And it seems that DR is found in equal numbers to DQ in the human intestine. Therefore, I don't really understand why you would choose to stain for DR instead of DQ?

Alberto Serrano-Pozo

I'm not sure about the porcine intestine. For activated microglia in the brain I use the Dako mouse monoclonal antibody CR3/43 which labels HLA-DR-DP-DQ, catalog number M0775.

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