Bisphosphonate can cause bone pains as its side effect. Mild bone pain is common and can be corrected by taking analgesics. However for severe bone pain discontinuation of treatment is recommended and other alternatives can be considered. This article will help you in finding your answer:
Article Diffuse skeletal pain after administration of alendronate
The mechanism of bone pain or in severe cases the osteonecrosis ( like that of jaw bone) is poorly understood as of now.
In the future, we might get a lucid explanation of various actions of bisphosphonates.
Besides it, RANK/RANKL interaction is revealing many newer associations and might unearth some more discoveries.
Although all oral and IV bisphosphonate preparations list musculoskeletal pain as a potential adverse effect in their prescribing information, the FDA recently issued an alert highlighting the possibility of severe and sometimes incapacitating bone, joint, and/or musculoskeletal pain that may occur at any point after patients begin taking a bisphosphonate. Although discontinuation of bisphosphonate therapy improves symptoms in some patients, others appear to have slow or incomplete resolution. Risk factors for and the incidence of this potential adverse effect of bisphosphonates are unknown.
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