Why aren't drugs implementing activation of cholinergic anti-inflammatory pathway (n-cholinomimetics, α7nAChR agonists, etc.) used in treatment of COVID-19?
It was found that activation of cholinergic anti-inflammatory pathway reduces the concentration of pro-inflammatory cytokines in the blood and organs during sepsis, and various infectious diseases, while significantly reducing mortality.
https://en.wikipedia.org/wiki/Cholinergic_anti-inflammatory_pathway#:~:text=The%20cholinergic%20anti%2Dinflammatory%20pathway,and%20regulates%20the%20inflammatory%20response.
(see^ https://www.researchgate.net/profile/PF_Zabrodskii/research
see^ https://pubmed.ncbi.nlm.nih.gov/?term=Zabrodskii+P.F. )
Article [Effect of armin on nonspecific resistance factors of the bo...
Article Variation in antiinfectious nonspecific resistance of the or...
Article P.F. Zabrodskii. Effect of acetylcholine on mortality of mic...
Article [The effect of anabasine on mortality and concentration of p...
Article Effect of α7n-Acetylcholine Receptor Activation and Antibodi...
Article P. F. Zabrodskii, M. S. Gromov, V. V. Maslyakov. Combined Ef...
Article Effects of reversible inhibition of cholinesterase and nicot...
I agree. We should be trying everything to help people.
While the merits of α7nAChR agonists in this context are unknown, and despite the regulatory mechanism of this receptor are poorly understood, these agents do seem to exhibit a low risk profile. Thus a comparison to the potential (unknown) benefits in patients, given a practical cost-benefit analysis, makes this a viable approach, in my opinion.
Dear Miky Timothy,
thank you so much!
activation of α7nAChRs monocytes and macrophages (reduction of proinflammatory cytokines production) is possible not only by selective α7nAChRs agonists but also by acetylcholine, n-cholinomimenics, reversible cholinesterase inhibitors, etc.
(see^ https://www.researchgate.net/profile/PF_Zabrodskii/research
see^ https://pubmed.ncbi.nlm.nih.gov/?term=Zabrodskii+P.F. )
I strongly agree. Besides α7nAChRs agonists, we should considerer using non-invasive neuromodulation which may be safer regarding interaction with other types of drugs. My group just published a pre-print addressing this subject, in case your interest: Article Neuromodulation and Inflammatory Reflex: Perspectives on the...
Dear Ana Carolina Pinheiro Campos,
thank you so much. It is a very interesting, wonderful article with theoretical and practical significance.
I congratulate you.
***
P.F. Zabrodskii
The Honored Worker of Science P.F. Zabrodskii discovered of the cholinergic anti-inflammatory pathway (phenomenon) in 1987 (http://en.wikipedia.org/wiki/Cholinergic_anti-inflammatory_pathway); developed a direction - " Immunotoxicology xenobiotics and pharmacological correction postintoxication immunodeficiency states ". The author of over 350 scientific papers (over 550 theses, articles, research reports etc.) The founder of scientific school in the field of immunotoxicology xenobiotics. https://ru.wikipedia.org/wiki/%D0%97%D0%B0%D0%B1%D1%80%D0%BE%D0%B4%D1%81%D0%BA%D0%B8%D0%B9,_%D0%9F%D0%B0%D0%B2%D0%B5%D0%BB_%D0%A4%D1%80%D0%B0%D0%BD%D1%86%D0%B5%D0%B2%D0%B8%D1%87
***
Why aren't drugs implementing activation of cholinergic anti-inflammatory pathway (cholinomimetics, α7nAChR agonists) used in treatment of COVID-19?
Along with other drugs!
***
P.F. Zabrodskii
The Honored Worker of Science P.F. Zabrodskii discovered of the cholinergic anti-inflammatory pathway (phenomenon) in 1987 (http://en.wikipedia.org/wiki/Cholinergic_anti-inflammatory_pathway); developed a direction - " Immunotoxicology xenobiotics and pharmacological correction postintoxication immunodeficiency states ". The author of over 350 scientific papers (over 550 theses, articles, research reports etc.) The founder of scientific school in the field of immunotoxicology xenobiotics. https://ru.wikipedia.org/wiki/%D0%97%D0%B0%D0%B1%D1%80%D0%BE%D0%B4%D1%81%D0%BA%D0%B8%D0%B9,_%D0%9F%D0%B0%D0%B2%D0%B5%D0%BB_%D0%A4%D1%80%D0%B0%D0%BD%D1%86%D0%B5%D0%B2%D0%B8%D1%87
If i concise the answer then we are not using drugs triggering cholinergic anti inflammatory pathway because the spike which are present in the crown on covid-19 virus are protein structure on which we can work with the help of RNA related vaccine we need rna related vaccine to stop it's replication once it's replication stops then only the cholinergic related medication is helpful
I write about the way, along with others, as a complement to them. But there is no vaccine yet. But there's a cytokine storm.
https://www.newscientist.com/term/cytokine-storm/
Diseases such as covid-19 and influenza can be fatal due to an overreaction of the body’s immune system called a cytokine storm. https://en.wikipedia.org/wiki/Cytokine_storm
Read more: https://www.newscientist.com/term/cytokine-storm/#ixzz6OaZTQlvn
P.F. Zabrodskii discovered of the cholinergic anti-inflammatory pathway (phenomenon) in 1987- http://en.wikipedia.org/wiki/Cholinergic_anti-inflammatory_pathway
It's sad that the author did not make reference to my articles. And I have expressed this idea in RG several times.
***
https://pubmed.ncbi.nlm.nih.gov/32378064/
Article Feasibility of Therapeutic Effects of the Cholinergic Anti-I...
Comment J Neuroimmune Pharmacol
. 2020 Jun;15(2):165-166. doi: 10.1007/s11481-020-09919-6. Epub 2020 May 7.
There is an alternative interpretation: the pathway is activated but in different contexts, produces different results.
go here to see the synergetic interpretation. A single peptidde- somatostatin- effects are experimnetal context dependent
- DOI: 10.1590/S0001-37652009000100006
- Source
- PubMed
P.F. Zabrodskii added an answer June 2
The idea Why aren't drugs implementing activation of cholinergic anti-inflammatory pathway (cholinomimetics, α7nAChR agonists, etc.) used in treatment of COVID-19? It was found that activation of cholinergic anti-inflammatory pathway reduces the concentration of pro-inflammatory cytokines in the blood and organs during sepsis, and various infectious diseases, while significantly reducing mortality.
https://en.wikipedia.org/wiki/Cholinergic_anti-inflammatory_pathway#:~:text=The%20cholinergic%20anti%2Dinflammatory%20pathway,and%20regulates%20the%20inflammatory%20response.
(see^ https://www.researchgate.net/profile/PF_Zabrodskii/research
see^ https://pubmed.ncbi.nlm.nih.gov/?term=Zabrodskii+P.F. )
Article [Effect of armin on nonspecific resistance factors of the bo...
Article Variation in antiinfectious nonspecific resistance of the or...
Article P.F. Zabrodskii. Effect of acetylcholine on mortality of mic...
Article [The effect of anabasine on mortality and concentration of p...
Article Effect of α7n-Acetylcholine Receptor Activation and Antibodi...
Article P. F. Zabrodskii, M. S. Gromov, V. V. Maslyakov. Combined Ef...
Article Effects of reversible inhibition of cholinesterase and nicot...
See:
https://www.researchgate.net/post/Why_arent_drugs_implementing_activation_of_cholinergic_anti-inflammatory_pathway_cholinomimetics_a7nAChR_agonists_used_in_treatment_of_COVID-19
***
https://www.researchgate.net/post/What_is_a_new_idea_How_are_new_ideas_born_in_science_art_and_politics
P.F. Zabrodskii added an answer June 2
The idea Why aren't drugs implementing activation of cholinergic anti-inflammatory pathway (cholinomimetics, α7nAChR agonists, etc.) used in treatment of COVID-19? It was found that activation of cholinergic anti-inflammatory pathway reduces the concentration of pro-inflammatory cytokines in the blood and organs during sepsis, and various infectious diseases, while significantly reducing mortality.
***
Article Feasibility of Therapeutic Effects of the Cholinergic Anti-I...
Feasibility of Therapeutic Effects of the Cholinergic Anti-Inflammatory Pathway on COVID-19 Symptoms.
Mazloom R.J Neuroimmune Pharmacol. 2020 Jun;15(2):165-166. doi: 10.1007/s11481-020-09919-6. Epub 2020 May 7.PMID: 32378064 Free PMC article. No abstract available.
To see optical profiles of spreading depression waves and excitotxic responses, look here:
The Kinetics of Non-Synaptically Triggered Acute Excitotoxic Responses in the Central Nervous System Observed Using Intrinsic Optical Signals
- April 2011
- CNS & neurological disorders drug targets 11(2):132-41
- DOI:
- 10.2174/187152712800269704
- Source
- PubMed
- 📷Vera Maura Fernandes de Lima
- Wolfgang Hanke
- In here you can compare the protective effect of magnesium and reduced glutathione with the alfa-seven
Dear Zabrodskii,
I read your papers, andworked with pre-clinical tests, also have an autoimmune process, so could be a customer.
The pathway ffrom pre to clinical methods is bumpy and physicians are afraid of acting outside aproved protocols. medicine became judicialized and insurance companies ruled. I understand your frustration, and I am eager to for the news of new approaches to the cytokines storm.
maybe storm is not always the right analogy, but an out of phase and incoordinate imune response can sometimes explain better the clinical signs and symptons.
As long as I can say...
The Honored Worker of Science P.F. Zabrodskii discovered of the cholinergic anti-inflammatory pathway (phenomenon) in 1987 (http://en.wikipedia.org/wiki/Cholinergic_anti-inflammatory_pathway); developed a direction - " Immunotoxicology xenobiotics and pharmacological correction postintoxication immunodeficiency states ". The author of over 350 scientific papers (over 550 theses, articles, research reports etc.) The founder of scientific school in the field of immunotoxicology xenobiotics. https://ru.wikipedia.org/wiki/%D0%97%D0%B0%D0%B1%D1%80%D0%BE%D0%B4%D1%81%D0%BA%D0%B8%D0%B9,_%D0%9F%D0%B0%D0%B2%D0%B5%D0%BB_%D0%A4%D1%80%D0%B0%D0%BD%D1%86%D0%B5%D0%B2%D0%B8%D1%87
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