is there any one suffer from same problem.. group gave antioxidant and drug showed results more negative than group which gave drug only .. and there was some cases of death in first group reverse what was expected.
thanks a lot Dr. Isaac
I experienced this condition in my study and in other researchers studies. for example we i treated the animals with Doxorubicin (anti cancer drug) synchronously with anti oxidant Quercetin for 28 consecutive day.
Good day. We also have experienced such situation (for example, in dislypidemia model combining herbal extract (high hydroxycinnamic acids content and also flavonoids including quercetin) with metformin have not improved the state of the internal organs especially the liver) and there is evidence about green tea constituents hepatotoxicity possibly proceeding from phenolic compounds. So I am completely agree with Dr. Isaac Karimi that the excessive peroxidative stress may arise. And some years ago too much attention was attracted to antioxidant mechanisms and many PhD students and other researchers even experienced problems when showing their supervisors the results not corresponding to the expectations of the great overcoming of the oxidative stress
Regards
Thank you dr. Olga
Dr.Isaac confirm on determine the best dose of anti oxidant .. I did an initial experiment to detect best dose and use it in principle experiment in my study.. but the results was as i explained in my question.. So Dr. how you dissolve this problem in your study?
specially the interaction group(antioxidant+drug) consider as the main group in the project .... thanks a lot.
In our study with metformin I also had other combination with a tincture except for theextract and it worked better. Previously I predominantly addressed the functional and biochemical values (kidney function, uric acid metabolism etc. and they were greatly improved by the studied drugs, so the antioxidant mechanisms were just the supplementary ones).
As for doxorubicin and quercetin, I have just remembered that the scientists of our university have worked on this problem (the department of clinical pharmacology and clinical pharmacy)
Maybe you will find it useful to compare the doses and other factors (the English abstracts are qiute informative)
http://dspace.nuph.edu.ua/bitstream/123456789/4524/1/04-09.pdf
http://elib.vsmu.by/bitstream/handle/123/5722/vf_2015_1_83-88.pdf?sequence=1&isAllowed=y
https://www.google.com.ua/url?sa=t&rct=j&q=&esrc=s&source=web&cd=3&cad=rja&uact=8&sqi=2&ved=0ahUKEwjpj4LalaLTAhUQKywKHYCvAwAQFggvMAI&url=http%3A%2F%2Firbis-nbuv.gov.ua%2Fcgi-bin%2Firbis_nbuv%2Fcgiirbis_64.exe%3FC21COM%3D2%26I21DBN%3DUJRN%26P21DBN%3DUJRN%26IMAGE_FILE_DOWNLOAD%3D1%26Image_file_name%3DPDF%2Fubfj_2013_4_60.pdf&usg=AFQjCNGA3pQnlcXS9DZpBES9XAv4eUDh4w&sig2=d62ZI4c311Z3E1OiF1CZvw&bvm=bv.152180690,d.bGg
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