Currently, WAXS is employed to study structural changes and ligand binding in proteins; however, the methods are not as fully developed for nucleic acids.

the above information is mentioned in the attached article (abstract). Now i want to know why is difficult to deal with nucleic acids by WAXS  

please help me

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4884185/

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