This is an interesting and important question. And Amit Kumar is partly right, the annual death rate is higher from lung cancer, but the incidence of lung cancer in the United States is lower than prostate and breast cancer. So yes as the question states - breast cancer in women and prostate cancer in men are the two most common invasive cancers based upon records in the U.S. Although these cancers come from different anatomical and physiological tissues, both these tissues share the common feature of requiring sex steroid-dependent development. Initially, these sex steroid hormones oestrogen and androgen can act as growth factors that protect these cancers form apoptosis, which I suggest is why these are the most common invasive cancers. So tumors from them are often hormone-dependent making oestrogen and androgen key drivers of both breast and prostate cancer etiology. They are not so classified, but one could consider oestrogen and androgen as being among the first recognized cancer growth factors. Although most breast and prostate tumors therefore usually respond to hormone therapy by inhibiting of tumor growth, resistance is a major and often fatal problem. So there is a critical need to identify strategies to avoid resistance. Furthermore, the development of metastatic hormone-resistant breast or prostate cancer is considered incurable. The challenge then is to strategically identify and chemically target interactions that continue to influence tumor growth in the face of hormone resistance. I believe that success in doing this will likely depend upon combining both systems-level network results with mechanistic bottom-up information and analyses, which unfortunately is not currently being done.