Hi all,
Analyzing DTI data, I am looking for a way to measure thalamic and cortical shift of a corticothalamic connection. My hypothesis is that, in patients a given fiber tract reaches the thalami (or cortex) rostrally, for example, compared to controls. However, I don’t know which toolbox I can use to do it. As far as I know, FSL doesn’t provide a good way to perform this analysis. Am I right?
Does anyone know a way to figure this?
Thanks!
Theo Marins.
Hi Alberto, thanks for the question. I believe that protrackx would give me information about probability rather that the structure itself. I am not sure if I am right. What do you think about it?
You should keep in mind that there are two way to perform tractography using deterministic or probabilistic models. Then, you can work each of one but the two way give you structural information itself.
Hi Theo,
Interesting, but quite difficult question. Current Fibertracking algorithms only give you "the most probable" fiberBundle-prientation. In addition, the thalamus is a highly interconnected region, which makes it hard to isolate fibertracts and to see, whether they end in a different cortex location.
One approach would be to create ROIs in the cortex and thalamus and use SPMs StreamlineTracking with Global FiberTracking data (Reisert et al.). You can use Freiburgs DTI toolbox to extract the interconnecting fibertracks (between your ROIs). All these toolboxes are matlab based.
A new module in MRtrix3 was recently introduced that can register diffusion data to other diffusion data. So, you could register you scans (e.g. clinical diffusion scans to the control diffusion scans) and the process will provide a transformation matrix. You can then explore that transformation matrix on a voxel-by-voxel (or fixel by fixel, or dixel by dixel) level to investigate the degree of shift. MRtrix3 has a very active forum whereby such questions can be asked.
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