Im trying to do some research into if i carried out this experiment which reagents would be best suited to give the best results.
Application of HPTLC with Densitometry for Evaluation of the Impact of ...
downloads.hindawi.com/journals/ijac/2017/4914292.pdf
by K Bober - 2017 - Cited by 1 - Related articlesAug 7, 2017 - Katarzyna Bober. Department of Analytical Chemistry, School of Pharmacy with theDivision of Laboratory Medicine, ... exposure to UV light which can give information about new substances, degradation products of diphenhydramine, which were ... It seems that TLC method of analysis of diphenhydramine.
Hi, in addition of the comment above, I think you can see the TLC conditions and reagent in Camag TLC data base:
http://www.camag.com/en/tlc_hptlc/customer_magazine_cbs/ccbs_database.cfm?method=query
Hello Catriona, acetic acid is not suitable for your experiment since your amine would be protonated and likely get stuck on the baseline.
Instead you can try either ethyl acetate/methanol (9:1) or dichloromethane/methanol (9:1). You can also add a drop of triethylamine.
You can have a look on the synthesis of diphenhydramine in the following publications:
Article π-Conjugated Triazenes: Intermediates That Undergo Oxidation...
Article Ruthenium-Catalyzed N-Alkylation of Amines and Sulfonamides ...
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