What is the reaction you want to do?

It is still possible to use DMAP, you can just remove the DMAP by another way like chromatography. Other possible alternatives include polymer supported DMAP, inorganic bases may also be possible depending on the reaction, or low boiling organic bases like triethylamine or pyridine although removing them on the rotavap may not be so straightforward.

You can use Pyridine instead of DMAP

You may use TEA or DIPEA, depends on the starting material what you are using.

Perhaps aqueous washes with a weaker acid (other than HCl) could be used to reove DMAP without deprotecting the Boc amine. Acetic or citric come to mind.

TEA or DIPEA will be perfect. U can also use some appropriate inorganic bases.

Triethylamine/pyridine commericially cheap amine

You can use DABCO, is a saturated bicyclic diamine.

DMAP can remove by column or else u can go through TEA or DIPEA

Dear A. Rana,

One thing...Whether your boc amine comound is sensitive to HCl? Or else you can use Dioxane.HCl/Diethyl Ether.HCl/methanol.HCl in dichloromethane at 0 oC.

In most of the above cases, HCl workup is required to remove organic bases(TEA, Pyridine etc.,) ....feeling doubt with DBU and DABCO or inorganic bases.

try DBU (easy to remove ,BP =85C)

You can remove DMAP easily by washing with aqueous CuSO4 solution.

Catalytic DMAP is used in combination with a base to accelerate a reaction such a Boc-protection, acylation etc. If you want for deprotonation you have to use different bases depending on substrate. But DMAP could be easily removable through column chromatography.

I work with DBU. It`s a good base, easy to remove.

you can use TEA or DIPEA AS base.

Can use DBU , Dioxane. HCl and TEA

Regards

Wash with 4%HCl, Sat.aq.NaHCO3 and brine and then dry the product by unhydrous magnesium sulfate, is so useful

Can be use TEA or DIPEA

Aula makes a good point - tBOC is sensitive to strong, anhydrous acids, but notat all to dilute aqueous HCl.