C5AR has been shown not to just be connected with inflammatory reactions, but seems to have direct actions on some brain area involved in pain perception.
Sorry Giustino but I can't answer the question ... I'm only an economist. However, I have a request for you and your colleagues on the status of modeled claims. I have just drafted a paper on economic evaluation articles published in Value in Health. I would appreciate any comments (and possible venues where these questions could be raised). With best wishes. Paul Langley