Which approach is the more recommended approach in calculate EQ5D values for patients in different country in a normal study (no cost analysis or comparative study between countries)? I want to evaluate treatment effect on PRO of 2 treatments, which occurs in all participating centers.
A) Transform EQ5D response via one general value set (e.g. US population OR European population)
B) Transform each EQ5D response via country-specific value set (e.g. Spanish and Portuguese patients will use the Spanish value set, Japanese patients use the Japanese value set, German patients use the German value set and African patients use the Zimbabwe value set and so on...)
Thanks in advance
Hi Christian,
The answer is that multiple versions of the EQ5D must be used, especially when you are talking about populations with different languages. Each version of the EQ5D has been validated only in its specific population. Thus, using one version on multiple different populations will result in inaccurate HUV numbers and essentially a substantial methodological weakness of whatever study you are looking to run. I hope this answers your question.
George
Thanks George for this competent answer.
But what do you mean with "inaccurate HUV numbers". Can you please explain it a bit more to me. Highly appreciated.
Christian
The answers to the EQ5D survey can be translated into health utility values (HUV). HUVs are the unit of Quality Adjusted Life Years (QALY), which is the unit of measurement used in cost utility analyses. The accuracy of the EQ5D representing HUVs is entirely dependent on the population that the particular version of the survey was validated on. Hopefully that helps.
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