Which way does the receptors on Golgi apparatus face? (facing the cytoplasm or the golgi sacs?)
Answering this part above is satisfying enough and I’m all gratitude. I’m asking this because I’m confused by the latest research below(if you are interested you can have a look):
In the latest research about neuroplasticity (Vargas MV et al., 2023), researchers found that 5-HT2A receptors, in neurons, are mainly intracellular on Golgi apparatus (not on cell membrane). They found this by realising that only hydrophobic 5-HT2AR agonists (which pass the hydrophobic cell membrane, like psychedelic) can exhibit an effect on enhancing dendritic growth. They confirmed the hypothesis by staining 5-HT2AR and they overlap with Golgi apparatus. This explains why 5-HT selective reuptake inhibitor does not have an effect on Major Depression: because 5-HT may not be the agonist of 5-HT2AR in neutron at all… My question is I forgot which way receptors on Golgi apparatus face: if they face the sacs, how can agonist like psychedelics be effective after all?
Vargas MV, Dunlap LE, Dong C, et al. Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors. Science. 2023;379(6633):700-706. doi:10.1126/science.adf0435