Dear Dr. Ghasemi,
I got curious and I'm willing to know which chemical reaction you will use for your AB conjugation?
If you're going to use Thiol/Maleimide reaction by introducing a terminal Cys, what your plan for site-specificity of the conjugation to AB would be? Because, as far as I know, there are Cys residues in the variable chains of ABs as well. I will really appreciate your response.
Thanks so much in advance
and best regards,
Farzad.