I know that astrogliosis form glial scar at the site of tissue damage however I am not sure in my answer because of the special reference to the MS in the question.
Thank you very much for your answers.
Dear Dr. Joshua, It is such a nice explanation and it really helps, I appreciated.
In regular MS they are astrocytes but in the Balo-type of lesion Drs Wayne Moore and Cedric Raine in Einstein found out that in the concentric rings of demyelination there were also oligodendroglial cells (regenerating ones?). Thus the question is why oligos are not surviving. You may have also read the old anecdoctal dogma that in MS plaques all nerve fibers are preserved!
Good luck for your investigations!
The astrocytic response seems to be variable and probably depends on the age of the lesion. In some cases, the astroglial response is extensive (see Raine in Chapter 15, The lesion in multiple sclerosis and chronic relapsing experimental allergic encephalomyelitis: A structural comparison. In Multiple Sclerosis Clinical and pathogenetic basis. Eds CS Raine, HF McFarland & WW Tourtellotte. Chapman & Hall Medical, London.) or in old senile plaques there is very little astroglial scar tissue (see Barnes, D., Munro, PMG., Youl, BD., Prineas, JW. McDonald, WI. The longstanding MS lesion. A quantitative MRI and electron microscopic study. Brain 114;1271-1280, 1991.)
I hope this helps.
Bob
- Badges
- Science topic