One dye works with infrared. NIAD-4

http://www.innovations-report.de/html/berichte/medizin_gesundheit/bericht-48317.html

Another one was shown to alleviate Alzheimer symptoms,

Thioflavin T

http://www.newscientist.com/article/mg21028064.600-dye-slows-ageing-and-alzheimers-protein-formation.html

http://www.nature.com/nature/journal/v472/n7342/full/nature09873.html

Regards,

Joachim (not a medic)

You can use a very basic dye i.e congo red further ThT is also an option

Dyes that bind Beta amyloid (Congo red/ ThioS) recognize the beta sheet core that forms within the plaques. These will be extracellular. I don't know if you can detect intraneuronal amyloid with these dyes. How about using an antibody that picks up amyloid in general, like 6E10 (Covance)?

Also, if you will be doing any multiphoton imaging, Methoxy XO4 will work as an anti-amyloid dye.

The amyloid fibers bind the dye Congo Red and then show green

birefringence when viewed between crossed polarizers.

Although ThT offers a reliable means of visualizing amyloid aggregates

in vitro, it suffers from two major drawbacks that hinder its clinical

use in living beings. First, ThT is weakly hydrophobic and does not

readily enter the brain, and second, its binding affinity to fibrils

is low.

FDA has approved the radioactive diagnostic agent florbetapir. As a

radioactive tracer, florbetapir binds to beta-amyloid plaque to make

it visible through PET scans of the brain. Under the brand name

Amyvid, it is the only FDA-approved imaging agent for amyloid plaque

on the marke.

http://www.diagnosticimaging.com/nuclear/content/article/113619/2070275

Luminescent conjugated polyelectrolyte probes has been reported for

detecting amyloids

Nilsson, K.P., Aslund, A., Berg, I., Nystro¨ m, S., Konradsson, P.,

Herland, A., Ingana ¨ s, O., Stabo-Eeg, F., Lindgren, M., Westermark,

G.T., et al. (2007). Imaging distinct conformational states of

amyloid-beta fibrils in Alzheimer’s disease using novel luminescent

probes. ACS Chem. Biol. 2, 553–560.

Another goo example is paper entitled “Novel Pentameric Thiophene

Derivatives for in Vitro and in Vivo Optical Imaging of a Plethora of

Protein Aggregates in Cerebral Amyloidoses” in ACS Chem. Biol., 2009,

4 (8), pp 673–684