I want to know the list of novel biopolymers allowed to use for the topical drug delivery.
Hyaluronic acid for instance..
check this
http://www.ncbi.nlm.nih.gov/pubmed/20499487
Shellac is well documented to use for drug delivery.Some papers:
http://www.sciencedirect.com/science/article/pii/S0939641107001476
http://informahealthcare.com/doi/abs/10.1080/03639040600559099
http://www.sciencedirect.com/science/article/pii/S0963996910000955
etc...
Topical drug delivery systems involve the introduction of a drug to the surface of the body, in a formulation which can be absorbed. Skin patches are an example of topical drug delivery systems. Other systems involve sprays applied to the mucus membranes of the nose, inhalation aerosols, eye drops, or creams which may be rubbed into the skin. These systems are often very easy for patients to use, which makes them appealing.In all cases, the goal of a drug delivery system is to get the right dosage to the right place. Patients tend to prefer methods which are painless and easy, which is why many pharmaceuticals. come in the form of topical and enteral methods which can be taken by mouth or applied directly to the
skin. In clinical environments, perenteral routes can be more common, especially for controlled substances, because these methods allow for greater control over how and when the drugs are used
The current and emerging approaches of optimizing the topical delivery of dermatological agents (small and large molecules) include the use of chemical
enhancers, bio-polymers (e.g. sodium hyaluronate), liposomes, particulate carriers (microspheres and lipid nanoparticles), topical sprays and foams, occlusion (via dressings and patches) topical peels, temperature (heat), iontophoresis, and ultrasound. These delivery approaches (when used solely or in a synergistic manner) are a significant improvement over conventional systems (creams, lotions, ointments and pastes) and have the potential to enhance efficacy and tolerability, improve patient compliance (including dermatology life quality), and also fulfil other unmet needs of the topical dermatological market
.
PLA, PEG, various functional and random polymers are used for drug delivery. Even various hydrocolloids are used for drug delivery.
I would assume by your question, you are looking to load drug into a biopolymer matrix and then apply it on the topical region and release the drug over a period of time. Correct me if i am wrong, but you can use many many generic synthetic polymer, many listed above, for this purpose. Case and point, band aid. In you case, i would be looking to focus on choose a polymer with relative quick drug releasing rate. Also, you might want to think of the adhesive one might want to use and its interaction between the polymer and the topical region.
After, the choice on the material need to much more parameter to make a intelligent chioce.
If i rem rightly, there is substantial use of silicon based topical patches for many purposes. You might want to look at that.
Dear Vinod,
Water soluble polymers like poly vinyl alcohol, poly vinyl pyrrolidone can also be used along with the above suggested polymers.
chitosan and alginate are bestcompatible to use as topical drug delivery
If you're looking for some form of nanocarrier for topical application you need to take into account its toxicity, so maybe think about water soluble polymers that are also biocompatible rather than thinking just about polymers with quick degradation rate.
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