After reading the editorial published in Nepal Journal of Epidemiology by Dr. Shrikant I Bangdiwala, Professor, Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA. I had a mind to think more about significance, p value and Confidence Interval.

Interested scientists are requested to write a letter to the editor for Dr. Shrikant's Editorial which can come up with a new change in the research. 

On 7 March 2016, the American Statistical Association (ASA) released a statement to improve the interpretation of statistical significance and p-values and their role in scientific research. In their concluding remarks, they state “Good statistical practice, as an essential component of good scientific practice, emphasizes principles of good study design and conduct, a variety of numerical and graphical summaries of data, understanding of the phenomenon under study, interpretation of results in context, complete reporting and proper logical and quantitative understanding of what data summaries mean. No single index should substitute for scientific reasoning”. The ASA statement also states: “Informally, a p-value is the probability under a specified statistical model that a statistical summary of the data (for example, the sample mean difference between two compared groups) would be equal to or more extreme than its observed value” .  The p-value is thus a single index, so where does it and ‘statistical significance’ stand within ‘good statistical practice’?

http://www.nepjol.info/index.php/NJE/article/view/14732

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