can anyone help me whether Mesenchymal stem cells generate mesenchymal cells or reverse is correct?
Mesenchymal stem cells can differentiated to many kind of mesoderm cells and even cells from ectoderm or endoderm! so what kind of cells you want to differentiated mesenchymal stem cells to it? if you mean fibroblast, yes it could be and recently many reports showing that "adipocytes can dedifferentiated to MSCs.
these are two papers which describe it.
Best,
Article Fibroblastic Differentiation of Human Mesenchymal Stem Cells...
Article Human Dedifferentiated Adipocytes Show Similar Properties to...
adipose, muscle, tendon, cartilage all retain a stem cell component (usually called progenitor cells). In regards de-differentiation I personally do not believe this. What they are possibly observing is the terminally differentiated cells dying off and the progenitor component proliferating. Be very careful of how you use the term de-differentiate, if cells are really capable of de-differentiation why would we need a stem cell???
Also within the native tissue that contains a stem cell component you will see tissue masking whereby the stem cells are masked by the tissue niche and may express markers native to the tissue.
thank you Sir. this answer is more appealing to me. but still I am not clear whether Mesenchymal stem cells generate mesenchymal cells or mesenchymal cells generate Mesenchymal stem cells.
mesenchymal stem cells are capable of differentiating into all cells derived from the mesoderm in embryonic development. also during the proliferation phase they produce daughter mesenchymal stem cells. you would be best looking at embryonic development and hierarchy of tissues and points of origin.
embryonic development: the mesoderm gives rise to mesenchymal stem cells which then produce subsequent cells that will become: cartilage, tendon, bone, adipose etc etc all the mature tissues should also contain a stem cell (progenitor cell) component.
Seema, I would advice you to read up on embryonic development and stem cell biology. there is a cellular hierarchy and that's the best place to start.
Hello
i agree with all researchers. this link will help you
Article Q&A: Mesenchymal stem cells — where do they come from and is...
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