Hello!
I'm having some trouble finding papers or literature regarding the metabolic activation and pathways of:
-Aliphatic amines
-Nitrosocompounds (both Aromatic and Aliphatic)
-Aliphatic nitro compounds
I've found plenty of info regarding aromatic amines and nitroaromatics but I'm lacking those above. Could you please help me? Any reference I could check?
It is related to electrophilic endproduct that could potentially bind to DNA or other biomolecules. Any info on that would also be very beneficial.
Thank you a lot!
Dear Andres Halabi sorry to see that your very interesting technical question has not yet received any expert answers. We work in synthetic inorganic chemistry, so that I'm certainly not a proven expert in this field. However, I noticed that you can find a number of suitable references when you search the internet for the individual classes of compounds, e.g. "metabolism of nitroso compounds into electrophilic intermediates". That why I found the following potentially useful article which might help you in your analysis:
Mechanisms of action of N-nitroso compounds
Article Mechanisms of action of N-nitroso compounds
Perhaps you can access the full text of this paper thropugh your institution. By the way, please pass my best regards to my colleague and friend Ramiro Arratia-Perez who is an emeritus professor at your institution. 😎
Good luck with your work and best wishes, Frank eEdelmann
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