When can a physcians stop ACE INHIBITORS in pt. With intractable cough? I mean after how long cough after ignition of drugs?
Angiotensin-converting enzyme inhibitor-induced cough - PubMed
Resolution typically occurs within 1 to 4 weeks after the cessation of therapy, but cough may linger for up to 3 months. The only uniformly effective treatment for ACE inhibitor-induced cough is the cessation of treatment with the offending agent.
Can easily shift to ARB like telmisartan
Dear Dr Ruqaya Adnan Salih Please see the following link:
https://journal.chestnet.org/article/S0012-3692(15)52845-6/fulltext
Kindly see also the following link:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)62609-8/fulltext
Please, see also the following article:
Article Pneumonia and ACE inhibitors - And cough
In practice, it is sometimes not immediately clear that a cough is caused by ACE inhibitors, because patients taking these drugs can have a cough as a symptom of the underlying disease. These can be pulmonological and cardiac patients. In those cases, when cough as a symptom of the underlying disease does not last long, it is important to ask whether patients are taking ACE inhibitors. For these reasons, we can say that there are many more such patients than the statistics give us. Such patients are often not identified. After discontinuation of ACE inhibitors cough cough quickly disappears (1-3 weeks). If it does not disappear during this time, you need to look for other causes of cough
Thank you very much Dr. Salman Ajlan for your answer and valuable link & article you provided.
Good evening.
You have to be sure that the cough is a side effect of these medicins. So, exclude other conditions that induce cough.
Generally, these iatrogenic cough is not associated with sputum, is very frecquent in the second part of the day and in the night. But, if you do not have time and opportunity to investigate, replace ACE inhibitors with a sartan. Keep contact with patient to find out the result. Cough is supposed to dissapear in 2-3 days, if ACE inhibitor is the cause.
Thank you Florina-Mihaela Filip-Ciubotaru for your answer and discussion.
The onset of ACE inhibitor-induced cough ranges from within hours of the first dose to months after the initiation of therapy. Resolution typically occurs within 1 to 4 weeks after the cessation of therapy, but cough may linger for up to 3 months. A cough caused by ACE inhibitors can only be treated by stopping the drug. With that said, it should never stop treatment without first talking to healthcare provider, depending on circumstances, the benefits of treatment may outweigh the concerns.
Article Angiotensin-Converting Enzyme Inhibitor-Induced Cough: ACCP ...
https://www.verywellhealth.com/lisinopril-causes-cough-1124151
Also, kindly check:
Article ACEI-induced cough: A review of current evidence and its pra...
Thanks again Dr. Manal Hadi Kanaan for your shared link. & valuable discussion.
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