The initiation of slip along MCT, MBT, STDS in the Himalayan fold thrust belt is well constrained, but I am unable to find any reliable estimates for the initiation of slip along MFT.
The Main Central Thrust (MCT) in the Himalayas is thought to have been active during the early Miocene, around 20-15 million years ago. This period of thrusting is thought to have been contemporaneous with extension in the Higher Himalayas, which is thought to have occurred due to the extrusion of material from beneath the MCT. This extension is thought to have continued until around 15-12 million years ago. After this time, the Lesser Himalayas began to grow, with thrusting along the Main Boundary Thrust (MBT) beginning around 7.5 million years ago and the Main Frontal Thrust (MFT) beginning around 1 million years ago. However, the timing of the initiation of these thrusts and the rate at which they have been active is still a topic of ongoing research and debate among geologists. Here are a few useful references:
Article Along-strike continuity of structure, stratigraphy, and kine...
Article Geometry and kinematics of Main Frontal thrust-related fault...
Article Holocene shortening across the Main Frontal Thrust zone in t...
Article Timing of recent out-of-sequence active deformation in the f...